Sia Analysis
Sensitization
Sensitization studies are performed to determine whether a test substance has the potential to produce local or systemic allergic and/or sensitizing adverse effects after repeated or prolonged exposure. For this purpose, different in vivo tests available: Guinea Pig Maximization Test (Magnusson-Kligman Method), Murine Local Lymph Node Test (LLNA), Buehler Test.
The OECD 442B test analyzes immunological reactions to assess skin sensitivity, and the ELISA (Enzyme-Linked Immunosorbent Assay) test plays a critical role in this process. ELISA tests are conducted in our facility with the latest technologies to ensure high sensitivity and accuracy. These tests are used to detect specific antibody-antigen interactions, especially in lymph nodes. The analyses we perform within the scope of the OECD 442B test are supported by the reliable data provided by ELISA tests. In this way, even substances at low concentrations in biological samples are analyzed accurately, and reliable and comprehensive results are obtained. Our ELISA tests meet the highest standards in your immunological analyses.
Guinea Pig Maximization Test is frequently performed by expert and experienced personnel in SİA Analysis Laboratories with GLP conformity declaration. In case of specific request, LLNA or Buehler tests are also performed. Sensitization tests are performed in accordance with national/international standards within the scope of OECD 406, OECD 442, EPA 870.2600 and ISO 10993-10.